understanding the embryonic stem cell niche how extracellular matrix influences cell fate and differentiation

embryonic stem cells cell niche extracellular matrix fate determination differentiation ecm proteins collagen laminin fibronectin adhesion migration organogenesis developmental biology signaling pathways gene expression pluripotent regenerative medicine therapy tissue engineering disorders diseases biomaterials microenvironment reprogramming factors growth scaffolding molecules biological processes biochemistry molecular research biotechnology treatment repair