understanding bone resorption the role of osteoclasts in mineral release and bone tissue breakdown

bone resorption osteoclasts mineral release tissue breakdown metabolism cellular activity health calcium matrix degradation remodeling skeletal system minerals osteoporosis biodynamics formation maintenance cartilage density phosphate alkaline phosphatase signaling pathways inflammatory response osteoblasts homeostasis turnover extracellular biomineralization microenvironment cell resorptive osteoprotegrin receptor activator rankl pathophysiology