the pathogenesis of acanthosis nigricans scheme

acanthosis activation antigen blood cancer cell cells cytokines dendritic dermal diabetes endocrine fibroblast hematopoietic hormone illustration immune increase infections inflammation inflammatory insulin insults interleukin keratinocites keratinocytes lymphocyte mediated medical metabolic nigricans pathogenesis pathogens problem proliferation receptors recruitment resistance responses scheme skin sterile stream structural surface syndromes synthesis system treatment vector