the mitotic kinase nek7 binds to inactive nrlp3 leading to the assembly and activation of the nlrp3 inflammasome

039 activation alzheimer autoimmune biochemistry cancer caspase cell complex cytokine death disease domain enzyme immune immunology inflammasome inflammation kinase macromolecule mitotic molecules nek7 neurodegenerative nrlp3 polypeptide proinflammatory protein pyroptosis system