rage receptor (mouse) hexamer, active form after ligand binding

rage oligomerization hexamer membrane receptor advanced glycosylation immunoglobulin diabetes inflammation tumour invasion cancer aggregation alzheimer 039 disease dementia amyloid plaque biological degenerative plaques aging cell protein molecules degeneration mouse active form ligand binding product-specific belongs superfamily involved alzheimer's invasion believed play essential role signal transduction position conformation transmembrane intracellular domains assumed