optogenetic stimulation of neuronal activity in the cerebral cortex for alzheimer's disease

optogenetic stimulation neuronal activity cerebral cortex alzheimer 039 disease research optogenetics brain neurodegeneration cognitive decline neural circuits optic fibers lightsensitive proteins neurotransmitters memory impairment experimental models neurological disorders therapeutic interventions progression protein aggregation synaptic plasticity excitability function neuroprotection animal studies tools gene expression networks behavioral outcomes excitatory neurons inhibitory aigenerated