human prion protein (hprp), chemical structure. associated with neurodegenerative diseases, including kuru, bse and creutzfeldt-

acid amino atoms bovine bse cd230 cellular conformation copper creutzfeldt cu disease encephalopathy folding health hprp human jakob kuru major misfolding model molecular molecule neurodegeneration neurodegenerative pdb1qlx peptide polymer polypeptide prion protein prp prpsc science scientific scrapie spongiform structure transmissible tse