epigenetics for diabetes theraphy

dna methylation histone modification acetylation gene expression chromatin remodeling noncoding rna microrna transcription factors genomic imprinting demethylation epigenome epigenetic marks methyltransferase acetyltransferase deacetylase inhibitors accessibility enhancer regions promoter cpg islands inheritance environmental influences metabolic programming insulin resistance betacell dysfunction hyperglycemia inflammation oxidative stress nutrient sensing transcriptional regulation