bone resorption process osteoclasts breaking down bone tissue for calcium release

bone resorption osteoclasts breaking tissue calcium release process degradation mineralization remodeling osteoporosis biodynamics cellular activity homeostasis nutrition alkaline phosphatase calcitonin parathyroid hormone extracellular matrix marrow multinucleated formation activation cytokines bicarbonate resorptive osteoblasts skeletal system dynamic equilibrium cycle mechanotransduction pathophysiology hormonal regulation