alzheimer disease dementia of amyloid plaques, neurofibrillary in brain, cognitive decline, memory loss, atrophy in hippocampus

alzheimer disease brain memory loss amyloid dementia neurofibrillary plaques tangles atrophy hippocampus human head amatomy x-ray neurodegeneration tau protein beta-amyloid impairment early-onset alzheimer#39aph39#s late-onset genetics risk factors mci vascular frontotemporal lewy body apoe gene cholinergic hypothesis acetylcholine neurotransmitters neuroinflammation positron emission tomography scans resonance imaging mri mini-mental state examination mmse research treatment medication generated plaques brain loss hippocampus hippocampusalzheimer#39aph39#s disease form dementia characterized accumulation leading loss progresses atrophy genetic factors developing alzheimer#39aph39#s especially alzheimer#39aph39#s research role protein aid diagnosing tests impairment neurotransmitters acetylcholine function disruptions alzheimer#39aph39#s additionally implicated progression disease detection through clinical caregiving challenging multidisciplinary intervention