advancements in car-t cell therapy: precision immunotherapy for cancer treatment

car-t immunotherapy lymphocytes cytokines biomarkers oncogene hematology neoplasm leukapheresis antigen apoptosis monoclonal genomics proteomics virology autologous allogeneic vivo transduction lentivirus retrovirus hematopoiesis transcriptomics bioinformatics tumorigenesis epitope microenvironment metastasis checkpoint cytokine-release myeloid lymphoid biosimilars chimeric nanomedicine epigenetics differentiation proliferation hematologic cytotoxicity pharmacokinetics glycoprotein virotherapy exosomes bispecific immunogenicity