3d image of pemetrexed skeletal formula

pemetrexed chemotherapy medication pleural mesothelioma non-small cell lung cancer nsclc carboplatin pembrolizumab folate antimetabolites dihydrofolate reductase dhfr purine pyrimidine thymidylate synthase glycinamide ribonucleotide formyltransferase garft rendering chemotherapy regimen antineoplastic chemo ctx cancer treatment anti-cancer anticancer oncology mitosis inhibit cytotoxic immunosuppression myelosuppression targeted therapies topoisomerase antimetabolite alkylating agents emetogenic chemotherapy-induced nausea vomiting cinv pharmacodynamics pharmacokinetics side effect adverse action iatrogenic overdose contraindications interaction