3d image of lonidamine skeletal formula

lonidamine derivative indazole-3-carboxylic acid aerobic glycolysis cancer cells mitochondrially hexokinase ehrlich ascites tumor atp anticancer agent brain tumour male contraceptive pill lonidamine mechanism action fda approval rendering chemotherapy chemotherapy regimen antineoplastic chemo ctx treatment anti-cancer anticancer anti-tumor oncology mitosis inhibit cytotoxic immunosuppression myelosuppression targeted therapies topoisomerase antimetabolite alkylating agents emetogenic chemotherapy-induced nausea vomiting cinv pharmacodynamics pharmacokinetics medication side effect adverse iatrogenic overdose contraindications